Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation.

doi:10.1038/ncomms14265

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Article

Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation.

Nature communications - 22 Feb 2017

Bjornsdottir Gyda, Benonisdottir Stefania, Sveinbjornsson Gardar, Styrkarsdottir Unnur, Thorleifsson Gudmar, Walters G Bragi, Bjornsson Aron, Olafsson Ingvar H, Ulfarsson Elfar, Vikingsson Arnor, Hansdottir Ragnheidur, Karlsson Karl O, Rafnar Thorunn, Jonsdottir Ingileif, Frigge Michael L, Kong Augustine, Oddsson Asmundur, Masson Gisli, Magnusson Olafur T, Gudbjartsson Tomas, Stefansson Hreinn, Sulem Patrick, Gudbjartsson Daniel, Thorsteinsdottir Unnur, Thorgeirsson Thorgeir E, Stefansson Kari

Abstract excerpt

Lumbar disc herniation (LDH) is common and often debilitating. Microdiscectomy of herniated lumbar discs (LDHsurg) is performed on the most severe cases to resolve the resulting sciatica. Here we perform a genome-wide association study on 4,748 LDHsurg cases and 282,590 population controls and discover 37 highly correlated markers associating with LDHsurg at 8q24.21 (between CCDC26 and GSDMC), represented by...

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PMID: 28223688
DOI: 10.1038/ncomms14265
PMCID: PMC5322534

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GSDMC

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