The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples.

doi:10.1038/s41467-021-27918-w

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The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples.

Nature communications - 1 Feb 2022

Barrett James E, Herzog Chiara, Jones Allison, Leavy Olivia C, Evans Iona, Knapp Susanne, Reisel Daniel, Nazarenko Tatiana, Kim Yoo-Na, Franchi Dorella, Ryan Andy, Franks Joanna, Bjørge Line, Zikan Michal, Cibula David, Harbeck Nadia, Colombo Nicoletta, Dudbridge Frank, Jones Louise, Sundström Karin, Dillner Joakim, Rådestad Angelique Flöter, Gemzell-Danielsson Kristina, Pashayan Nora, Widschwendter Martin

Abstract excerpt

Genetic and non-genetic factors contribute to breast cancer development. An epigenome-based signature capturing these components in easily accessible samples could identify women at risk. Here, we analyse the DNA methylome in 2,818 cervical, 357 and 227 matched buccal and blood samples respectively, and 42 breast tissue samples from women with and without breast cancer. Utilising cervical liquid-based cytology...

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Identifiers

PMID: 35105882
DOI: 10.1038/s41467-021-27918-w
PMCID: PMC8807602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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