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Article

Lymphokine-induced cytotoxic cell generation in thymus and spleen cell cultures.

Journal of biological regulators and homeostatic agents - 1 Jan 2000

Biasi G, Rivarollo R, Colmagro R, Ronchese F, Collavo D

Abstract excerpt

The effect of a supernatant (SN-A) obtained from PMA-stimulated IL-2 producing EL-4 cells on cytotoxic cell induction in thymocyte and splenocyte cultures was evaluated. SN-A, but not recombinant IL-2 alone, induced cytotoxic cell differentiation in thymus cell cultures, thus indicating that factors distinct from IL-2 are required for effector cell generation. INF-gamma takes part in the process, and Ia+...

Topics

Animals
Cell Division
Cells, Cultured
Cytotoxicity Tests, Immunologic
Lymphokines
Mice
Mice, Inbred C57BL
Phenotype
Spleen
T-Lymphocytes, Cytotoxic
Thymus Gland

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Source

Identifiers

PMID: 3509738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3509738-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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