Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lymphokine-induced cytotoxic cell generation in thymus and spleen cell cultures.

Journal of biological regulators and homeostatic agents - 1 Jan 2000

Biasi G, Rivarollo R, Colmagro R, Ronchese F, Collavo D

Abstract excerpt

The effect of a supernatant (SN-A) obtained from PMA-stimulated IL-2 producing EL-4 cells on cytotoxic cell induction in thymocyte and splenocyte cultures was evaluated. SN-A, but not recombinant IL-2 alone, induced cytotoxic cell differentiation in thymus cell cultures, thus indicating that factors distinct from IL-2 are required for effector cell generation. INF-gamma takes part in the process, and Ia+...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Cells, Cultured
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Phenotype

Share to Spleen

Share to T-Lymphocytes, Cytotoxic

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 3509738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lymphokine-induced cytotoxic cell generation in thymus and spleen cell cultures.PMID 3509738Read ↗

Characterization of OKT3-initiated lymphokine-activated effectors expanded with interleukin 2 and tumor necrosis factor alpha.Semantic proximity Read ↗

TNF-alpha potentiation of the lymphokine-activated killer response of murine thymus cells.Semantic proximity Read ↗

Generation and characterization of lymphokine-activated killer cells from non-Hodgkin's lymphoma patients.Semantic proximity Read ↗

The phenotype of type 1 and type 2 CD8+ T cells activated in vitro is affected by culture conditions and correlates with effector activity.Semantic proximity Read ↗

In vitro cytolytic activity of lymphocytes from tumor-draining lymph nodes is associated with increased numbers of CD8+ cells and increased cytokine production.Semantic proximity Read ↗

In vivo kinetics and characterization of IFN-gamma-producing cells during a thymus-independent immune response.Semantic proximity Read ↗

Further characterization of cytotoxic T cells generated by short-term culture of human peripheral blood lymphocytes with interleukin-2 and anti-CD3 mAb.Semantic proximity Read ↗

High release of tumor necrosis factor alpha, interferon gamma and interleukin-6 by adherent lymphokine-activated killer cells phenotypically derived from T cells.Semantic proximity Read ↗

Generation of natural killer-like cytotoxicity from human thymocytes with interleukin-2.Semantic proximity Read ↗

Human spleen and peripheral blood lymphocytes activated by interleukin-2 have similar phenotypic and functional characteristics.Semantic proximity Read ↗

Simultaneous production of interleukin 2, interleukin 4 and interferon-gamma by activated human blood lymphocytes.Semantic proximity Read ↗

Combined activation of murine lymphocytes with staphylococcal enterotoxin and interleukin-2 results in additive cytotoxic activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.