High release of tumor necrosis factor alpha, interferon gamma and interleukin-6 by adherent lymphokine-activated killer cells phenotypically derived from T cells.

doi:10.1007/BF01612762

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Article

High release of tumor necrosis factor alpha, interferon gamma and interleukin-6 by adherent lymphokine-activated killer cells phenotypically derived from T cells.

Journal of cancer research and clinical oncology - 1 Jan 1991

Koberda J, Bergmann L, Mitrou P S, Hoelzer D

Abstract excerpt

Adherent lymphokine-activated killer cells (A-LAK) are highly potent cytotoxic cells, which are shown to be derived not only from natural killer (NK)/K cells but phenotypically also from T cells. The generation and phenotypical and functional characterisation of these T-cell-derived A-LAK are described. In contrast to non-adherent cells (NA-LAK) and unseparated LAK (UN-LAK), these mostly CD3+ CD56+ CD8+ cells...

Topics

Cell Adhesion
Cell Division
Cells, Cultured
Cytotoxicity, Immunologic
Humans
Interferon-gamma
Interleukin-2
Interleukin-6
Killer Cells, Lymphokine-Activated
Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasms, Experimental

Phenotype

T-Lymphocytes

Time Factors

Tumor Cells, Cultured

Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 1909699
DOI: 10.1007/BF01612762

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1909699-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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