Article
Combined activation of murine lymphocytes with staphylococcal enterotoxin and interleukin-2 results in additive cytotoxic activity.
Cancer immunology, immunotherapy : CII - 1 Apr 1994
Belfrage H, Bhiladvala P, Hedlund G, Dohlsten M, Kalland T
Abstract excerpt
This report demonstrates that in vitro activation of murine spleen cells with interleukin-2 (IL-2) or the bacterial superantigen staphylococcal enterotoxin A (SEA) results in different patterns of activation and function of cytotoxic cells. Lymphokine-activated killer activity and antibody-dependent cellular cytotoxicity (ADCC) are mainly mediated by IL-2 activated natural killer (NK) cells. SEA is the most...
Topics
- Animals
- Cytotoxicity, Immunologic
- Drug Synergism
- Enterotoxins
- Interleukin-2
- Lymphocyte Activation
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta