Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simultaneous production of interleukin 2, interleukin 4 and interferon-gamma by activated human blood lymphocytes.

European journal of immunology - 1 Jul 1990

Andersson U, Andersson J, Lindfors A, Wagner K, Möller G, Heusser C H

Abstract excerpt

The production of interleukin 2 (IL 2), IL 4 and interferon-gamma (IFN-gamma) by in vitro activated unselected human blood mononuclear cells was studied at a single-cell level. Individual lymphokine-synthesizing cells were identified by intracellular immunofluorescent staining using cytokine-specific monoclonal or polyclonal antibodies. Cultures from adult blood donors revealed a biphasic kinetic production...

Topics

Adult
Antibodies, Monoclonal
Cytoplasm
Fluorescent Antibody Technique
Humans
In Vitro Techniques
Infant, Newborn
Interferon-gamma
Interleukin-2
Interleukin-4
Ionomycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Leukocytes, Mononuclear

Lymphocyte Activation

Phenotype

Tetradecanoylphorbol Acetate

Source

Identifiers

PMID: 2117537
DOI: 10.1002/eji.1830200727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2117537-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simultaneous production of interleukin 2, interleukin 4 and interferon-gamma by activated human blood lymphocytes.PMID 2117537Read ↗

Distinct gene expression profiles of human type 1 and type 2 T helper cellsSemantic proximity Read ↗

Recurrent Stimulation of Natural Killer Cell Clones with K562 Expressing Membrane-Bound Interleukin-21 Affects Their Phenotype, Interferon-γ Production, and LifespanSemantic proximity Read ↗

T-independent and T-dependent B lymphoblasts: helper T cells prime for interleukin 2-induced growth and secretion of immunoglobulins that utilize downstream heavy chains.Semantic proximity Read ↗

The cell surface phenotype of human natural interferon-alpha producing cells as determined by flow cytometry.Semantic proximity Read ↗

Recurrent Stimulation of NK Cell Clones with K562 Expressing Membrane-Bound IL-21 Affects Their Phenotype, IFN-γ Production and LifespanSemantic proximity Read ↗

NK and LAK activities from human marrow progenitors. I. The effects of interleukin-2 and interleukin-1.Semantic proximity Read ↗

Interleukin-2-induced lymphoproliferative responses.Semantic proximity Read ↗

Development of four donor-specific phenotypes in human long-term lymphokine-activated killer cell cultures.Semantic proximity Read ↗

Differential interleukin secretion by in vitro activated human CD45RA and CD45RO CD4+ T cell subsets.Semantic proximity Read ↗

Identification of a novel human thymocyte subset with a phenotype of CD3- CD4+ CD8 alpha + beta-1. Possible progeny of the CD3- CD4- CD8- subset.Semantic proximity Read ↗

Phenotypic and functional heterogeneity of human T cell clones producing gamma-interferon.Semantic proximity Read ↗

IL-2 Receptor Blockade Inhibits Late, But Not Early, IFN-γ and CD40 Ligand Expression in Human T Cells: Disruption of Both IL-12-Dependent and -Independent Pathways of IFN-γ ProductionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.