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Article

Mitochondrial targets in IDH1-mutated cholangiocarcinoma.

Hepatology communications - 1 Mar 2026

Carvalho Camila, Wuchu Fulei, Peterson Nicole, Nagrath Deepak, Mohan Arathi, Sahai Vaibhav

Abstract excerpt

Cholangiocarcinoma (CCA), a subset of biliary tract cancers, remains a therapeutically challenging malignancy with poor long-term survival despite recent advances in targeted therapies. Recent data suggest that IDH1-mutated CCA exhibits unique mitochondrial vulnerabilities. In this report, we discuss the emerging role of mitochondrial metabolism as a target in IDH1-mutated CCA, including preclinical evidence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41758056
DOI: 10.1097/HC9.0000000000000909
PMCID: PMC12947996

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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