Article
Identification of a specific immunophenotype associated with a consistent pattern of genetic mutations including SRFS2 and gene expression profile in MDS.
Cytometry. Part B, Clinical cytometry - 1 Mar 2023
Weiß Elisabeth, Walter Wencke, Meggendorfer Manja, Baer Constance, Haferlach Claudia, Haferlach Torsten, Kern Wolfgang
Abstract excerpt
BACKGROUND: Myelodysplastic syndromes (MDS) comprise a heterogeneous group of diseases classified by comprehensive diagnostics. Identification of homogeneous subgroups is desirable to understand differences in clinical course and to develop targeted treatment approaches. We identified a specific CD11b/CD16 expression pattern in granulocytes associated with reduced CD45 expression in myeloid progenitor cells (MPC)...
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