Article
The clinical implication of SRSF2 mutation in patients with myelodysplastic syndrome and its stability during disease evolution.
Blood - 11 Oct 2012
Wu Shang-Ju, Kuo Yuan-Yeh, Hou Hsin-An, Li Li-Yu, Tseng Mei-Hsuan, Huang Chi-Fei, Lee Fen-Yu, Liu Ming-Chih, Liu Chia-Wen, Lin Chien-Ting, Chen Chien-Yuan, Chou Wen-Chien, Yao Ming, Huang Shang-Yi, Ko Bor-Sheng, Tang Jih-Luh, Tsay Woei, Tien Hwei-Fang
Abstract excerpt
Recurrent somatic mutation of SRSF2, one of the RNA splicing machinery genes, has been identified in a substantial proportion of patients with myelodysplastic syndrome (MDS). However, the clinical and biologic characteristics of MDS with this mutation remain to be addressed. In this study, 34 (14.6%) of the 233 MDS patients were found to have SRSF2 mutation. SRSF2 mutation was closely associated with male sex (P...
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