Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical and prognostic profile of SRSF2 and related spliceosome mutations in patients with acute myeloid leukemia.

Molecular biology reports - 1 Aug 2023

Jia Wenbo, Guo Xiaodong, Wei Yihong, Liu Jinting, Can Can, Wang Ruiqing, Yang Xinyu, Ji Chunyan, Ma Daoxin

Abstract excerpt

BACKGROUND: Mutations in splicing factor (SF) genes are frequently detected in myelodysplastic syndrome, but their clinical and prognostic relevance in acute myeloid leukemia (AML) have rarely been reported. METHODS: A total of 368 newly diagnosed non-M3 AML patients were included in this study. Next generation sequencing including four SF genes was performed on the genomicDNA. The clinical features and survival...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Mutation

Share to Prognosis

Share to RNA Splicing Factors

Share to Serine-Arginine Splicing Factors

Share to Spliceosomes

Source

Identifiers

PMID: 37344641
DOI: 10.1007/s11033-023-08597-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical and prognostic profile of SRSF2 and related spliceosome mutations in patients with acute myeloid leukemia.PMID 37344641Read ↗

Clinical and prognostic profile of SRSF2 and related spliceosome mutations in patients with acute myeloid leukemiaSemantic proximity Read ↗

Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes.Semantic proximity Read ↗

Splicing factor mutations predict poor prognosis in patients with de novo acute myeloid leukemia.Semantic proximity Read ↗

Mutations in Splicing Factor Genes in Myeloid Malignancies: Significance and Impact on Clinical FeaturesSemantic proximity Read ↗

SRSF2 mutations in primary myelofibrosis: significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival.Semantic proximity Read ↗

Prognostic significance of SRSF2 mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia: a meta-analysis.Semantic proximity Read ↗

Acute Myeloid Leukemia with Myelodysplasia-Related Gene MutationsSemantic proximity Read ↗

Prognostic value of SRSF2 mutations in patients with de novo myelodysplastic syndromes: A meta-analysis.Semantic proximity Read ↗

Morphologic, immunophenotypic, molecular genetic, and clinical characterization in patients with SRSF2-mutated acute myeloid leukemia.Semantic proximity Read ↗

The clinical implication of SRSF2 mutation in patients with myelodysplastic syndrome and its stability during disease evolution.Semantic proximity Read ↗

Mechanistic Insights of Aberrant Splicing with Splicing Factor Mutations Found in Myelodysplastic Syndromes.Semantic proximity Read ↗

RNA splicing as a therapeutic target in myelodysplastic syndromes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.