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Article

Plasma protein-based and polygenic risk scores serve complementary roles in predicting inflammatory bowel disease.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2025

Woerner Jakob, Westbrook Thomas, Jeong Seokho, Shivakumar Manu, Greenplate Allison R, Apostolidis Sokratis A, Lee Seunggeun, Nam Yonghyun, Kim Dokyoon

Abstract excerpt

Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), has a significant genetic component and is increasingly prevalent due to environmental factors. Current polygenic risk scores (PRS) have limited predictive power and cannot inform time of symptom onset. Circulating proteomics profiling offers a novel, non-invasive approach for understanding the inflammatory state of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39670393
DOI: 10.1142/9789819807024_0037
PMCID: PMC11649021

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