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ARP2 /3 complex affects myofibroblast differentiation and migration in pancreatic ductal adenocarcinoma

29 Oct 2024

Abstract excerpt

Abstract The ARP2/3 complex, which orchestrates actin cytoskeleton organization and lamellipodia formation, has been implicated in the initiation of pancreatic ductal adenocarcinoma (PDAC). This study aims to clarify its impact on the activity of cancer‐associated fibroblasts (CAFs), key players in PDAC progression, and patient outcomes. Early pancreatic carcinogenesis was modeled in p48 Cre ; LSL‐Kras G12D mice...

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PMID: 39472297
DOI: 10.1002/ijc.35246

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