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Article

Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains.

Genetics - 1 Sept 2009

Dimitrov Lazar N, Brem Rachel B, Kruglyak Leonid, Gottschling Daniel E

Abstract excerpt

The mitochondrial genome (mtDNA) is required for normal cellular function; inherited and somatic mutations in mtDNA lead to a variety of diseases. Saccharomyces cerevisiae has served as a model to study mtDNA integrity, in part because it can survive without mtDNA. A measure of defective mtDNA in S. cerevisiae is the formation of petite colonies. The frequency at which spontaneous petite colonies arise varies by...

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Identifiers

PMID: 19581448
DOI: 10.1534/genetics.109.104497
PMCID: PMC2746160

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Source receipt: pubmed, retrieved 7 Sept 2026.

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