Rare variants in hypermutable genes underlie common morphology and growth traits in wild Saccharomyces paradoxus.

Abstract excerpt

Understanding the molecular basis of common traits is a primary challenge of modern genetics. One model holds that rare mutations in many genetic backgrounds may often phenocopy one another, together explaining the prevalence of the resulting trait in the population. For the vast majority of phenotypes, the role of rare variants and the evolutionary forces that underlie them are unknown. In this work, we use a...

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