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Article

Gene-Regulatory Potential of 25-Hydroxyvitamin D3 and D2

13 Jul 2022

Abstract excerpt

Human peripheral blood mononuclear cells (PBMCs) represent a highly responsive primary tissue that is composed of innate and adaptive immune cells. In this study, we compared modulation of the transcriptome of PBMCs by the vitamin D metabolites 25-hydroxyvitamin D3 (25(OH)D3), 25(OH)D2 and 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3). Saturating concentrations of 1,25(OH)2D3, 25(OH)D3 and 25(OH)D2 resulted after 24 h...

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Identifiers

PMID: 35911100
DOI: 10.3389/fnut.2022.910601

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