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Article

The Migratory Properties and Numbers of T Regulatory Cell Subsets in Circulation Are Differentially Influenced by Season and Are Associated With Vitamin D Status.

Frontiers in immunology - 1 Jan 2020

Lamikanra Abigail A, Tsang Hoi Pat, Elsiddig Shaza, Spencer Michael, Curnow Elinor, Danby Robert, Roberts David J

Abstract excerpt

The control of peripheral immune responses by FOXP3+ T regulatory (Treg) cells is essential for immune tolerance. However, at any given time, Treg frequencies in whole blood can vary more than fivefold between individuals. An understanding of factors that influence Treg numbers and migration within and between individuals would be a powerful tool for cellular therapies that utilize the immunomodulatory properties...

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Identifiers

PMID: 32508805
DOI: 10.3389/fimmu.2020.00685
PMCID: PMC7248210

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