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T Helper Cell Lineage-Defining Transcription Factors: Potent Targets for Specific GVHD Therapy?

5 Jan 2022

Abstract excerpt

Allogenic hematopoietic stem cell transplantation (allo-HSCT) represents a potent and potentially curative treatment for many hematopoietic malignancies and hematologic disorders in adults and children. The donor-derived immunity, elicited by the stem cell transplant, can prevent disease relapse but is also responsible for the induction of graft-versus-host disease (GVHD). The pathophysiology of acute GVHD is not...

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PMID: 35069590
DOI: 10.3389/fimmu.2021.806529

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