Article
Dynamic regulation of effector IFN-γ-producing and IL-17-producing T cell subsets in the development of acute graft-versus-host disease.
Molecular medicine reports - 1 Feb 2016
Zhao Kai, Ruan Suhong, Yin Lingling, Zhao Dongmei, Chen Chong, Pan Bin, Zeng Lingyu, Li Zhenyu, Xu Kailin
Abstract excerpt
Graft-versus-host disease (GVHD) as the predominant complication of allogeneic hematopoietic stem cell transplantation remains to be fully understood. It is known that the cytokines produced by allogeneic reactive effector CD4+ and CD8+ T cells are involved in GVHD. However, the regulation and coordination of IFN-γ-producing and IL-17-producing effector T cells remain unclear. The present study aimed to...
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