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Article

Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors

28 Jun 2004

Abstract excerpt

Hepatoblasts give rise to both mature hepatocytes and cholangiocytes. While Notch signaling has been implicated in the formation of bile ducts composed of cholangiocytes, little is known about the mechanism of lineage commitment of hepatoblasts. Here we describe the role of the Notch pathway in hepatoblast differentiation. Immunohistochemical analysis showed that Jagged1 was expressed in the cells surrounding the...

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Share to Epigenetics and DNA Methylation
Share to Liver physiology and pathology
Share to Pediatric Hepatobiliary Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15226394
DOI: 10.1242/jcs.01169

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Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factorsPMID 15226394Read ↗

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