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Article

Liver‐specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice†‡

18 Apr 2008

Abstract excerpt

UNLABELLED: The Notch pathway is an evolutionary conserved, intercellular signaling pathway that plays an important role in cell fate specification and the embryonic development of many organs, including the liver. In humans, mutations in the Notch receptor ligand Jagged1 gene result in defective intrahepatic bile duct (IHBD) development in Alagille syndrome. Developmental abnormalities of IHBD in mice doubly...

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PMID: 18666240
DOI: 10.1002/hep.22381

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Liver‐specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice†‡PMID 18666240Read ↗

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