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Article

An HLA-G/SPAG9/STAT3 axis promotes brain metastases

13 Feb 2023

Abstract excerpt

Brain metastases (BM) are the most common brain neoplasm in adults. Current BM therapies still offer limited efficacy and reduced survival outcomes, emphasizing the need for a better understanding of the disease. Herein, we analyzed the transcriptional profile of brain metastasis initiating cells (BMICs) at two distinct stages of the brain metastatic cascade-the "premetastatic" or early stage when they first...

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PMID: 36780531
DOI: 10.1073/pnas.2205247120

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