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Article

The role of SF3B1 and NOTCH1 in the pathogenesis of leukemia.

IUBMB life - 1 Mar 2023

Abolhasani Shiva, Hejazian Seyyed Sina, Karpisheh Vahid, Khodakarami Atefeh, Mohammadi Hamed, Gholizadeh Navashenaq Jamshid, Hojjat-Farsangi Mohammad, Jadidi-Niaragh Farhad

Abstract excerpt

The discovery of new genes/pathways improves our knowledge of cancer pathogenesis and presents novel potential therapeutic options. For instance, splicing factor 3b subunit 1 (SF3B1) and NOTCH1 genetic alterations have been identified at a high frequency in hematological malignancies, such as leukemia, and may be related to the prognosis of involved patients because they change the nature of malignancies in...

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PMID: 35848163
DOI: 10.1002/iub.2660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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