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Article

Explaining cancer type specific mutations with transcriptomic and epigenomic features in normal tissues.

Scientific reports - 30 Jul 2018

Tiong Khong-Loon, Yeang Chen-Hsiang

Abstract excerpt

Most cancer driver genes are involved in generic cellular processes such as DNA repair, cell proliferation and cell adhesion, yet their mutations are often confined to specific cancer types. To resolve this paradox, we explained mutation frequencies of selected genes across tumor types with four features in the corresponding normal tissues from cancer-free subjects: mRNA expression and chromatin accessibility of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30061703
DOI: 10.1038/s41598-018-29861-1
PMCID: PMC6065413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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