Article
Remarkable difference of somatic mutation patterns between oncogenes and tumor suppressor genes.
Oncology reports - 1 Dec 2011
Liu Haoxuan, Xing Yuhang, Yang Sihai, Tian Dacheng
Abstract excerpt
Cancers arise owing to mutations that confer selective growth advantages on the cells in a subset of tumor suppressor and/or oncogenes. To understand oncogenesis and diagnose cancers, it is crucial to discriminate these two groups of genes by using the difference in their mutation patterns. Here, we investigated>120,000 mutation samples in 66 well-known tumor suppressor genes and oncogenes of the COSMIC database,...
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