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Article

Identification and Characterization of an Exonic Duplication in PALB2 in a Man with Synchronous Breast and Prostate Cancer.

International journal of molecular sciences - 8 Jan 2022

Bouras Ahmed, Lafaye Cyril, Leone Melanie, Kherraf Zine-Eddine, Martin-Denavit Tanguy, Fert-Ferrer Sandra, Calender Alain, Boutry-Kryza Nadia

Abstract excerpt

PALB2 (partner and localizer of BRCA2), as indicated by its name, is a BRCA2-interacting protein that plays an important role in homologous recombination (HR) and DNA double-strand break (DSB) repair. While pathogenic variants of PALB2 have been well proven to confer an increased risk of breast cancer, data on its involvement in prostate cancer (PrC) have not been clearly demonstrated. We investigated, using...

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Identifiers

PMID: 35054852
DOI: 10.3390/ijms23020667
PMCID: PMC8775416

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Identification and Characterization of an Exonic Duplication in PALB2 in a Man with Synchronous Breast and Prostate Cancer.PMID 35054852Read ↗

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Contribution of large genomic rearrangements in PALB2 to familial breast cancer: implications for genetic testing.Semantic proximity Read ↗

Comprehensive sequencing of PALB2 in patients with breast cancer suggests PALB2 mutations explain a subset of hereditary breast cancer.Semantic proximity Read ↗

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