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Article

Gene of the month: PALB2.

Journal of clinical pathology - 1 Feb 2023

Hamdan Omar, Nowak Klaudia M

Abstract excerpt

The partner and localiser of BRCA2 (PALB2) gene, located on chromosome 16, functions as a tumour suppressor that plays a critical role in homologous recombination repair after DNA double-strand breaks. It encodes proteins involved in the BRCA2 and BRCA1, and RAD51 pathways. Heterozygous germline mutations in PALB2 have been implicated in the development of breast, pancreatic and ovarian cancers. Whereas biallelic...

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fanconi Anemia Complementation Group N Protein

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Source

Identifiers

PMID: 36600573
DOI: 10.1136/jcp-2022-208461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

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Gene of the month: PALB2.PMID 36600573Read ↗

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PALB2/FANCN: recombining cancer and Fanconi anemia.Semantic proximity Read ↗

Two recurrent pathogenic/likely pathogenic variants in PALB2 account for almost half of PALB2 positive families in SloveniaSemantic proximity Read ↗

Clinical outcomes in women with breast cancer and a PALB2 mutation: a prospective cohort analysis.Semantic proximity Read ↗

PALB2 and the risks for cancer: implications for clinical care.Semantic proximity Read ↗

Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.Semantic proximity Read ↗

Reviewing the characteristics of BRCA and PALB2-related cancers in the precision medicine eraSemantic proximity Read ↗

The Role of PALB2 in the DNA Damage Response and Cancer Predisposition.Semantic proximity Read ↗

Role of PALB2 Polymorphisms with Regard to Susceptibility to Female Breast Cancer Risk in the Chinese Population.Semantic proximity Read ↗

Integrated Bioinformatics Analysis of PALB2 Reveals Expression Patterns, Molecular Interactions, and Prognostic Significance in Breast CancerSemantic proximity Read ↗

PALB2: research reaching to clinical outcomes for women with breast cancerSemantic proximity Read ↗

Spectrum and characteristics of germline PALB2 pathogenic variants in 1556 early-onset breast cancer patients in China.Semantic proximity Read ↗

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