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Article

A novel PALB2 truncating mutation in an Italian family with male breast cancer.

Oncology reports - 1 Mar 2015

Vietri Maria Teresa, Caliendo Gemma, Casamassimi Amelia, Cioffi Michele, De Paola Maria Laura, Napoli Claudio, Molinari Anna Maria

Abstract excerpt

Male breast cancer (MBC) is a rare disease, accounting for ~1% of all breast cancer cases worldwide. Although other genes are also involved, predisposing genetic factors to MBC include germline mutations in the BRCA genes (BRCA2). Among the other genes, partner and localizer of BRCA2 (PALB2) is considered a moderate-penetrance breast cancer susceptibility gene that may also play a role in MBC predisposition....

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Source

Identifiers

PMID: 25529982
DOI: 10.3892/or.2014.3685

Genes

PALB2
BRCA2
RAD51

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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A novel PALB2 truncating mutation in an Italian family with male breast cancer.PMID 25529982Read ↗

Whole-exome sequencing and targeted gene sequencing provide insights into the role of PALB2 as a male breast cancer susceptibility gene.Semantic proximity Read ↗

PALB2: a novel inactivating mutation in a Italian breast cancer family.Semantic proximity Read ↗

Mutation analysis of PALB2 gene in French breast cancer families.Semantic proximity Read ↗

Mutations in BRCA2 and PALB2 in male breast cancer cases from the United States.Semantic proximity Read ↗

Pleomorphic/solid lobular carcinoma of male breast with PALB2 germline mutation: case report and literature review.Semantic proximity Read ↗

Insight into genetic susceptibility to male breast cancer by multigene panel testing: Results from a multicenter study in ItalySemantic proximity Read ↗

A PALB2 germline mutation associated with hereditary breast cancer in Italy.Semantic proximity Read ↗

The PALB2 gene is a strong candidate for clinical testing in BRCA1- and BRCA2-negative hereditary breast cancer.Semantic proximity Read ↗

BRCA and PALB2 mutations in a cohort of male breast cancer with one bilateral case.Semantic proximity Read ↗

Prevalence of PALB2 mutations in breast cancer patients in multi-ethnic Asian population in Malaysia and Singapore.Semantic proximity Read ↗

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Male breast cancer risk associated with pathogenic variants in genes other than BRCA1/2: an Italian case-control study.Semantic proximity Read ↗

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