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The Longevity-Associated Variant of BPIFB4 Reduces Senescence in Glioma Cells and in Patients' Lymphocytes Favoring Chemotherapy Efficacy.

Cells - 15 Jan 2022

Puca Annibale Alessandro, Lopardo Valentina, Montella Francesco, Di Pietro Paola, Cesselli Daniela, Rolle Irene Giulia, Bulfoni Michela, Di Sarno Veronica, Iaconetta Giorgio, Campiglia Pietro, Vecchione Carmine, Beltrami Antonio Paolo, Ciaglia Elena

Abstract excerpt

Glioblastoma (GBM) is the most common primary brain cancer with the median age at diagnosis around 64 years, thus pointing to aging as an important risk factor. Indeed, aging, by increasing the senescence burden, is configured as a negative prognostic factor for GBM stage. Furthermore, several anti-GBM therapies exist, such as temozolomide (TMZ) and etoposide (ETP), that unfortunately trigger senescence and the...

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Identifiers

PMID: 35053408
DOI: 10.3390/cells11020294
PMCID: PMC8774353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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