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Article

IFN-γ Triggered IFITM2 Expression to Induce Malignant Phenotype in Elderly GBM.

Journal of molecular neuroscience : MN - 1 Dec 2023

Liang Tingyu, Wang Xiaoxuan, Wang Yu, Ma Wenbin

Abstract excerpt

Advanced age is an important risk factor for the worse clinical presentation of gliomas, especially glioblastoma (GBM). The tumor microenvironment (TME) in elderly GBM (eGBM) patients is considerably different from that in young ones, which causes the inferior clinical outcome. Based on the data from the Chinese Glioma Genome Atlas RNA sequence (CGGA RNA-seq), the Cancer Genome Atlas RNA array (TCGA RNA-array),...

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PMID: 37889394
DOI: 10.1007/s12031-023-02156-5

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