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Article

V600EBRAF Inhibition Induces Cytoprotective Autophagy through AMPK in Thyroid Cancer Cells.

International journal of molecular sciences - 3 Jun 2021

Jiménez-Mora Eva, Gallego Beatriz, Díaz-Gago Sergio, Lasa Marina, Baquero Pablo, Chiloeches Antonio

Abstract excerpt

The dysregulation of autophagy is important in the development of many cancers, including thyroid cancer, where V600EBRAF is a main oncogene. Here, we analyse the effect of V600EBRAF inhibition on autophagy, the mechanisms involved in this regulation and the role of autophagy in cell survival of thyroid cancer cells. We reveal that the inhibition of V600EBRAF activity with its specific inhibitor PLX4720 or the...

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Identifiers

PMID: 34204950
DOI: 10.3390/ijms22116033
PMCID: PMC8199856

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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