Article
A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction.
Autophagy - 1 Oct 2013
Budina-Kolomets Anna, Hontz Robert D, Pimkina Julia, Murphy Maureen E
Abstract excerpt
The ARF tumor suppressor, encoded by the CDKN2A gene, has a well-defined role regulating TP53 stability; this activity maps to exon 1β of CDKN2A. In contrast, little is known about the function(s) of exon 2 of ARF, which contains the majority of mutations in human cancer. In addition to controlling TP53 stability, ARF also has a role in the induction of autophagy. However, whether the principal molecule involved...
Topics
- Animals
- Autophagy
- Cells, Cultured
- Cyclin-Dependent Kinase Inhibitor p16
- Humans
- Mice
- Mitochondria
- Mutation
- Tumor Suppressor Protein p53
- Tumor Suppressor Proteins