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Article

A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction.

Autophagy - 1 Oct 2013

Budina-Kolomets Anna, Hontz Robert D, Pimkina Julia, Murphy Maureen E

Abstract excerpt

The ARF tumor suppressor, encoded by the CDKN2A gene, has a well-defined role regulating TP53 stability; this activity maps to exon 1β of CDKN2A. In contrast, little is known about the function(s) of exon 2 of ARF, which contains the majority of mutations in human cancer. In addition to controlling TP53 stability, ARF also has a role in the induction of autophagy. However, whether the principal molecule involved...

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Identifiers

PMID: 23939042
DOI: 10.4161/auto.25831
PMCID: PMC4623555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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