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Article

Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation.

Molecular cell - 24 Oct 2013

Shen Che-Hung, Yuan Ping, Perez-Lorenzo Rolando, Zhang Yaqing, Lee Sze Xian, Ou Yang, Asara John M, Cantley Lewis C, Zheng Bin

Abstract excerpt

BRAF is an oncogenic protein kinase that drives cell growth and proliferation through the MEK-ERK signaling pathway. BRAF inhibitors have demonstrated antitumor efficacy in melanoma therapy but have also been found to be associated with the development of cutaneous squamous cell carcinomas (cSCCs...

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Source

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Identifiers

PMID: 24095280
DOI: 10.1016/j.molcel.2013.08.044
PMCID: PMC3892895

Genes

BRAF
KSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24095280-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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