Article
Unique molecular characteristics of NAFLD-associated liver cancer accentuate β-catenin/TNFRSF19-mediated immune evasion.
Journal of hepatology - 1 Aug 2022
Wong Alissa Michelle, Ding Xiaofan, Wong Aikha Melissa, Xu Mingjing, Zhang Luyao, Leung Howard Ho-Wai, Chan Anthony Wing-Hung, Song Qi Xiu, Kwong Joseph, Chan Loucia Kit-Ying, Man Matthew, He Mian, Chen Jinna, Zhang Zhe, You Wenxing, Lau Coleen, Yu Allen, Wei Yingying, Yuan Yunfei, Lai Paul Bo-San, Zhao Jingmin, Man Kwan, Yu Jun, Kahn Michael, Wong Nathalie
Abstract excerpt
BACKGROUND & AIMS: The hepatic manifestation of the metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), can lead to the development of hepatocellular carcinoma (HCC). Despite a strong causative link, NAFLD-HCC is often underrepresented in systematic genome explorations. METHODS: Herein, tumor-normal pairs from 100 patients diagnosed with NAFLD-HCC were subject to next-generation sequencing....
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