Article
Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits.
Journal of hepatology - 1 Feb 2014
Marquardt Jens U, Seo Daekwan, Andersen Jesper B, Gillen Matthew C, Kim Myoung Soo, Conner Elizabeth A, Galle Peter R, Factor Valentina M, Park Young Nyun, Thorgeirsson Snorri S
Abstract excerpt
BACKGROUND & AIMS: Human hepatocarcinogenesis is as a multi-step process starting from dysplastic lesions to early carcinomas (eHCC) that ultimately progress to HCC (pHCC). However, the sequential molecular alterations driving malignant transformation of the pre-neoplastic lesions are not clearly defined. This lack of information represents a major challenge in the clinical management of patients at risk....
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