Article
Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish.
PLoS genetics - 1 Mar 2011
Rodríguez-Marí Adriana, Wilson Catherine, Titus Tom A, Cañestro Cristian, BreMiller Ruth A, Yan Yi-Lin, Nanda Indrajit, Johnston Adam, Kanki John P, Gray Erin M, He Xinjun, Spitsbergen Jan, Schindler Detlev, Postlethwait John H
Abstract excerpt
Mild mutations in BRCA2 (FANCD1) cause Fanconi anemia (FA) when homozygous, while severe mutations cause common cancers including breast, ovarian, and prostate cancers when heterozygous. Here we report a zebrafish brca2 insertional mutant that shares phenotypes with human patients and identifies a novel brca2 function in oogenesis. Experiments showed that mutant embryos and mutant cells in culture experienced...
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