Article
Association of NOS1AP variants and depression phenotypes in schizophrenia.
Journal of affective disorders - 1 Dec 2015
Cheah Sern-Yih, Lawford Bruce R, Young Ross McD, Morris C Phillip, Voisey Joanne
Abstract excerpt
BACKGROUND: The nitric oxide synthase 1 adaptor protein gene (NOS1AP) has previously been recognised as a schizophrenia susceptibility gene due to its role in glutamate neurotransmission. The gene is believed to inhibit nitric oxide (NO) production activated by the N-methyl-d-aspartate (NMDA) receptor and reduced NO levels have been observed in schizophrenia patients. However, association studies investigating...
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