Article
Genetic association analysis of functional polymorphisms in neuronal nitric oxide synthase 1 gene (NOS1) and mood disorders and fluvoxamine response in major depressive disorder in the Japanese population.
Neuropsychobiology - 1 Jan 2010
Okumura Takenori, Kishi Taro, Okochi Tomo, Ikeda Masashi, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Kawashima Kunihiro, Tsunoka Tomoko, Inada Toshiya, Ozaki Norio, Iwata Nakao
Abstract excerpt
BACKGROUND/AIM: Nitric oxide has been reported to play a role in neural transmitter release and N-methyl-D-aspartate receptor activation, as well as to be related to oxidative stress. Abnormalities in both of these mechanisms are thought to be involved in the pathophysiology of mood disorders including major depressive disorder (MDD) and bipolar disorder (BP). In addition, several lines of evidence support an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.