Article
The genetic contribution of the NO system at the glutamatergic post-synapse to schizophrenia: further evidence and meta-analysis.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jan 2014
Weber H, Klamer D, Freudenberg F, Kittel-Schneider S, Rivero O, Scholz C-J, Volkert J, Kopf J, Heupel J, Herterich S, Adolfsson R, Alttoa A, Post A, Grußendorf H, Kramer A, Gessner A, Schmidt B, Hempel S, Jacob C P, Sanjuán J, Moltó M D, Lesch K-P, Freitag C M, Kent L, Reif A
Abstract excerpt
NO is a pleiotropic signaling molecule and has an important role in cognition and emotion. In the brain, NO is produced by neuronal nitric oxide synthase (NOS-I, encoded by NOS1) coupled to the NMDA receptor via PDZ interactions; this protein-protein interaction is disrupted upon binding of NOS1 adapter protein (encoded by NOS1AP) to NOS-I. As both NOS1 and NOS1AP were associated with schizophrenia, we here...
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