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Article

A putative cis-acting polymorphism in the NOS1 gene is associated with schizophrenia and NOS1 immunoreactivity in the postmortem brain.

Schizophrenia research - 1 Aug 2010

Cui Huxing, Nishiguchi Naoki, Yanagi Masaya, Fukutake Masaaki, Mouri Kentaro, Kitamura Noboru, Hashimoto Takeshi, Shirakawa Osamu, Hishimoto Akitoyo

Abstract excerpt

Schizophrenia is a devastating neurodevelopmental disorder whose genetic influences remain elusive. Recent genome-wide scans revealed that rare structural variants disrupted multiple genes in neurodevelopmental pathways, which strongly implicate nitric oxide (NO) signaling in schizophrenia. NO acts as a second messenger of N-methyl-D aspartate receptor activation, which further interacts with both dopaminergic...

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Identifiers

PMID: 20605417
DOI: 10.1016/j.schres.2010.05.003

Genes

NOS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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