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Article

Recombinant interferon alpha-2 modulates hairy cell phenotype "in vitro".

Journal of biological regulators and homeostatic agents - 1 Jan 2000

Fattorossi A, Dolei A, Pizzolo J G, Cafolla A, Mandelli F, Dianzani F

Abstract excerpt

The "in vitro" effect of IFN-alpha on the phenotypic profile of atypical cells from 5 hairy cell leukemia patients was investigated in a 72 hr culture assay. Cytochemical investigations revealed a dramatic decrease in the cytoplasmic content of acid phosphatase and tartrate resistant acid phosphatase in the absence of any apparent morphological modification. Flow cytometry showed that IFN-alpha markedly reduced...

Topics

Adult
Antigens, Differentiation
Cell Count
Cell Separation
Female
Flow Cytometry
Histocytochemistry
Humans
Interferon Type I
Leukemia, Hairy Cell
Leukocytes, Mononuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Phenotype

Recombinant Proteins

Source

Identifiers

PMID: 3504087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3504087-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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