Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recombinant interferon alpha-2 modulates hairy cell phenotype "in vitro".

Journal of biological regulators and homeostatic agents - 1 Jan 2000

Fattorossi A, Dolei A, Pizzolo J G, Cafolla A, Mandelli F, Dianzani F

Abstract excerpt

The "in vitro" effect of IFN-alpha on the phenotypic profile of atypical cells from 5 hairy cell leukemia patients was investigated in a 72 hr culture assay. Cytochemical investigations revealed a dramatic decrease in the cytoplasmic content of acid phosphatase and tartrate resistant acid phosphatase in the absence of any apparent morphological modification. Flow cytometry showed that IFN-alpha markedly reduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation
Share to Cell Count
Share to Cell Separation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to Histocytochemistry

Share to Leukocytes, Mononuclear

Share to Phenotype

Share to Recombinant Proteins

Source

Identifiers

PMID: 3504087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recombinant interferon alpha-2 modulates hairy cell phenotype "in vitro".PMID 3504087Read ↗

The biology of hairy cells.Semantic proximity Read ↗

An interferon resistant variant of the hairy-cell leukemic cell line, Eskol: biochemical and immunological characterization.Semantic proximity Read ↗

Flow cytometry of peripheral blood and bone marrow cells from patients with hairy cell leukemia: phenotype of hairy cells, lymphocyte subsets and detection of minimal residual disease after treatment.Semantic proximity Read ↗

A variant form of hairy cell leukemia resistant to alpha-interferon: clinical and phenotypic characteristics of 17 patients.Semantic proximity Read ↗

Biochemical and immunological phenotype alterations in human monoblastoid cell line U-937 induced by physiological (interferon-alpha, retinoic acid) and nonphysiological (phorbol ester) inducers.Semantic proximity Read ↗

Response patterns of hairy cell leukemia to B-cell mitogens and growth factors.Semantic proximity Read ↗

[Changes in immunologic phenotype of cells in hairy cell leukemia].Semantic proximity Read ↗

Phorbol ester-induced hairy cell features on chronic lymphocytic leukemia cells in vitro.Semantic proximity Read ↗

Induction of B-cell chronic lymphocytic leukaemia and hairy cell leukaemia like phenotypes by phorbol ester treatment of normal peripheral blood B-cells.Semantic proximity Read ↗

Effects of lymph node stromal cells on the differentiation of a cell line established from an atypical prolymphocytic leukemia with phenotypes of both chronic lymphocytic and hairy cell leukemias.Semantic proximity Read ↗

Mechanisms accounting for the defective natural killer activity in patients with hairy cell leukemia.Semantic proximity Read ↗

Interleukin-6 functions as an intracellular growth factor in hairy cell leukemia in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.