Effects of lymph node stromal cells on the differentiation of a cell line established from an atypical prolymphocytic leukemia with phenotypes of both chronic lymphocytic and hairy cell leukemias.

Abstract excerpt

We investigated the effects of stromal cells, obtained from lymph nodes with various lymphoid disorders and characterized immunocytochemically as fibroblasts, on the maturation of a cell line "HN" established from an atypical PLL (prolymphocytic leukemia) having phenotypic characteristics of both CLL (chronic lymphocytic leukemia) and HCL (hairy cell leukemia). Coculture with stromal cells, irrespective of the...

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