Article
Phorbol ester-induced hairy cell features on chronic lymphocytic leukemia cells in vitro.
American journal of hematology - 1 Aug 1992
al-Katib A, Wang C Y, McKenzie S, Clarkson B D, Koziner B
Abstract excerpt
Leukemic cells from eight patients with chronic lymphocytic leukemia were isolated and cultured in the continuous presence of 12-O-tetradecanoylphorbol 13-acetate (TPA) at a concentration of 1.6 x 10(-9) M for 4-10 days. Aliquots of cells were then analyzed at intervals of 24-72 hr for changes in...
Topics
- Acid Phosphatase
- Aged
- Antigens, CD
- Antigens, Differentiation, B-Lymphocyte
- CD11 Antigens
- Cell Adhesion Molecules
- Dose-Response Relationship, Drug
- Electrophoresis, Polyacrylamide Gel
- Female
- Humans
- Lectins
- Leukemia, Hairy Cell
- Leukemia, Lymphocytic, Chronic, B-Cell
- Lymphocytes
- Male
- Microscopy, Electron
- Middle Aged
- Phenotype