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Article

Interleukin-6 functions as an intracellular growth factor in hairy cell leukemia in vitro.

The Journal of clinical investigation - 1 Nov 1993

Barut B, Chauhan D, Uchiyama H, Anderson K C

Abstract excerpt

The role of interleukin-6 (IL-6) in the growth of B cell derived hairy cell leukemia (HCL) was characterized. Purified hairy cells (HCs) did not increase DNA synthesis in vitro in response to exogenous IL-6; however, they expressed IL-6 receptor (IL-6R) mRNA and bound directly fluorochrome labeled IL-6. IL-6 mRNA was not detectable in tumor cells by Northern blotting, but was evident using PCR amplification....

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Identifiers

PMID: 8227350
DOI: 10.1172/JCI116839
PMCID: PMC288416

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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