Article
Interleukin-6 functions as an intracellular growth factor in hairy cell leukemia in vitro.
The Journal of clinical investigation - 1 Nov 1993
Barut B, Chauhan D, Uchiyama H, Anderson K C
Abstract excerpt
The role of interleukin-6 (IL-6) in the growth of B cell derived hairy cell leukemia (HCL) was characterized. Purified hairy cells (HCs) did not increase DNA synthesis in vitro in response to exogenous IL-6; however, they expressed IL-6 receptor (IL-6R) mRNA and bound directly fluorochrome labele...
Topics
- Antigens, Surface
- B-Lymphocytes
- Cell Separation
- Growth Substances
- Humans
- Interleukin-6
- Leukemia, Hairy Cell
- Oligonucleotides, Antisense
- Phenotype
- RNA, Messenger
- Receptors, Interleukin
- Receptors, Interleukin-6
- Recombinant Proteins
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha