Article
An interferon resistant variant of the hairy-cell leukemic cell line, Eskol: biochemical and immunological characterization.
Leukemia research - 1 Nov 1993
Ozes O N, Klein S B, Reiter Z, Taylor M W
Abstract excerpt
The B-lymphoblastoid cell line Eskol, which is composed of differentiated cells resembling hairy-cell leukemia, has been used to study the effects of type I interferon in vitro. In order to study the mechanism of delayed interferon therapy resistance, a hairy-cell leukemia-like clonal cell line (IREs-4) was isolated from Eskol after 4 months of exposure to r-metIFN-con1. When compared to Eskol cells, the IREs-4...
Topics
- Blotting, Northern
- Cell Division
- Cytotoxicity Tests, Immunologic
- Drug Resistance
- Genetic Variation
- HLA-DR Antigens
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Humans
- Interferon Type I