Article
Mechanisms accounting for the defective natural killer activity in patients with hairy cell leukemia.
Blood - 1 Apr 1990
Trentin L, Zambello R, Agostini C, Ambrosetti A, Chisesi T, Raimondi R, Bulian P, Pizzolo G, Semenzato G
Abstract excerpt
Natural killer (NK) cell activity is severely impaired in untreated patients with hairy cell leukemia (HCL). In an attempt to investigate whether this impairment is related to a defect at the target cell binding and/or at the post target cell binding level, we evaluated the peripheral blood monon...
Topics
- Adult
- Aged
- Antigens, CD
- Cell Line
- Cytotoxicity, Immunologic
- Female
- Humans
- Interferon Type I
- Killer Cells, Natural
- Killer Factors, Yeast
- Kinetics
- Lectins
- Leukemia, Hairy Cell
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Male
- Middle Aged
- Phenotype
- Proteins