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Article

Mutant alleles of the Drosophila trithorax gene produce common and unusual homeotic and other developmental phenotypes.

Genetics - 1 May 1999

Breen T R

Abstract excerpt

trithorax (trx) encodes chromosome-binding proteins required throughout embryogenesis and imaginal development for tissue- and cell-specific levels of transcription of many genes including homeotic genes of the ANT-C and BX-C. trx encodes two protein isoforms that contain conserved motifs including a C-terminal SET domain, central PHD fingers, an N-terminal DNA-binding homology, and two short motifs also found in...

Topics

Alleles
Animals
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Gene Expression Regulation
Genes, Homeobox
Genes, Lethal
Genotype
Models, Genetic
Mutagenesis
Penetrance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Signal Transduction

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 10224264
DOI: 10.1093/genetics/152.1.319
PMCID: PMC1460610

Genes

SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10224264-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutant alleles of the Drosophila trithorax gene produce common and unusual homeotic and other developmental phenotypes.PMID 10224264Read ↗

Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each.Semantic proximity Read ↗

A homeotic mutation in the trithorax SET domain impedes histone binding.Semantic proximity Read ↗

The Drosophila trithorax proteins contain a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal proteins.Semantic proximity Read ↗

The role of ATXR6 expression in modulating genome stability and transposable element repression in Arabidopsis.Semantic proximity Read ↗

Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance.Semantic proximity Read ↗

The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains.Semantic proximity Read ↗

A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes.Semantic proximity Read ↗

ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing.Semantic proximity Read ↗

TRAUCO, a Trithorax-group gene homologue, is required for early embryogenesis in Arabidopsis thaliana.Semantic proximity Read ↗

ULTRAPETALA trxG genes interact with KANADI transcription factor genes to regulate Arabidopsis gynoecium patterning.Semantic proximity Read ↗

The Drosophila trithorax group gene tonalli (tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein.Semantic proximity Read ↗

Functional dissection of the ash2 and ash1 transcriptomes provides insights into the transcriptional basis of wing phenotypes and reveals conserved protein interactions.Semantic proximity Read ↗

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