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Article

Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity: a protocol for an adaptive recall by genotype study.

BMC medical genomics - 12 Jan 2022

Nickerson Aidan P, Corbin Laura J, Timpson Nicholas J, Phillips Keith, Pickering Anthony E, Dunham James P

Abstract excerpt

BACKGROUND: Pain is a complex polygenic trait whose common genetic underpinnings are relatively ill-defined due in part to challenges in measuring pain as a phenotype. Pain sensitivity can be quantified, but this is difficult to perform at the scale required for genome wide association studies (GWAS). Existing GWAS of pain have identified surprisingly few loci involved in nociceptor function which contrasts...

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Identifiers

PMID: 35022050
DOI: 10.1186/s12920-022-01156-5
PMCID: PMC8753821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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