Genes contributing to pain sensitivity in the normal population: an exome sequencing study.

doi:10.1371/journal.pgen.1003095

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genes contributing to pain sensitivity in the normal population: an exome sequencing study.

PLoS genetics - 1 Jan 2012

Williams Frances M K, Scollen Serena, Cao Dandan, Memari Yasin, Hyde Craig L, Zhang Baohong, Sidders Benjamin, Ziemek Daniel, Shi Yujian, Harris Juliette, Harrow Ian, Dougherty Brian, Malarstig Anders, McEwen Robert, Stephens Joel C, Patel Ketan, Menni Cristina, Shin So-Youn, Hodgkiss Dylan, Surdulescu Gabriela, He Wen, Jin Xin, McMahon Stephen B, Soranzo Nicole, John Sally, Wang Jun, Spector Tim D

Abstract excerpt

Sensitivity to pain varies considerably between individuals and is known to be heritable. Increased sensitivity to experimental pain is a risk factor for developing chronic pain, a common and debilitating but poorly understood symptom. To understand mechanisms underlying pain sensitivity and to search for rare gene variants (MAF<5%) influencing pain sensitivity, we explored the genetic variation in individuals'...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exome

Share to Gene Expression Regulation

Share to Gene Regulatory Networks

Share to Hot Temperature

Share to Pain

Share to Pain Threshold

Share to Sensitivity and Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 23284290
DOI: 10.1371/journal.pgen.1003095
PMCID: PMC3527205

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genes contributing to pain sensitivity in the normal population: an exome sequencing study.PMID 23284290Read ↗

Genetic components of human pain sensitivity: a protocol for a genome-wide association study of experimental pain in healthy volunteersSemantic proximity Read ↗

Genomic methods for clinical and translational pain research.Semantic proximity Read ↗

Individual differences in pain sensitivity: Genetic and environmental contributionsSemantic proximity Read ↗

Genetics of pain: From rare Mendelian disorders to genetic predisposition to pain.Semantic proximity Read ↗

Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes.Semantic proximity Read ↗

Genetic architecture of human pain perception.Semantic proximity Read ↗

Resilience to Pain: A Peripheral Component Identified Using Induced Pluripotent Stem Cells and Dynamic ClampSemantic proximity Read ↗

Human pain and genetics: some basicsSemantic proximity Read ↗

Genetic basis of pain variability: recent advances.Semantic proximity Read ↗

Pain genes.Semantic proximity Read ↗

Investigating genotype–phenotype relationship of extreme neuropathic pain disorders in a UK national cohortSemantic proximity Read ↗

Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.