Article
A GNAS mutation found in pancreatic intraductal papillary mucinous neoplasms induces drastic alterations of gene expression profiles with upregulation of mucin genes.
PloS one - 1 Jan 2014
Komatsu Hirotake, Tanji Etsuko, Sakata Naoaki, Aoki Takeshi, Motoi Fuyuhiko, Naitoh Takeshi, Katayose Yu, Egawa Shinichi, Unno Michiaki, Furukawa Toru
Abstract excerpt
GNAS, a gene encoding G protein stimulating α subunit, is frequently mutated in intraductal papillary mucinous neoplasms (IPMNs), which are indolent and slow-growing pancreatic tumors that secrete abundant mucin. The GNAS mutation is not observed in conventional ductal adenocarcinomas of the pancreas. To determine the functional significance of the GNAS mutation in pancreatic ductal lineage cells, we examined in...
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