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Article

GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling.

Gastroenterology - 1 Nov 2018

Ideno Noboru, Yamaguchi Hiroshi, Ghosh Bidyut, Gupta Sonal, Okumura Takashi, Steffen Dana J, Fisher Catherine G, Wood Laura D, Singhi Aatur D, Nakamura Masafumi, Gutkind J Silvio, Maitra Anirban

Abstract excerpt

BACKGROUND & AIMS: Mutations at hotspots in GNAS, which encodes stimulatory G-protein, α subunits, are detected in approximately 60% of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. We generated mice with KRAS-induced IPMNs that also express a constitutively active form of GNAS in pancreas and studied tumor development. METHODS: We generated p48-Cre; LSL-KrasG12D;...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Neoplasms, Cystic, Mucinous, and Serous

Share to Pancreatic Neoplasms

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Share to Proto-Oncogene Proteins p21(ras)

Share to YAP-Signaling Proteins

Source

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Identifiers

PMID: 30142336
DOI: 10.1053/j.gastro.2018.08.006
PMCID: PMC6219919

Genes

GNAS
KRAS
YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling.PMID 30142336Read ↗

<i>Gnas</i> <sup>R201C</sup> Induces Murine Pancreatic Cystic Neoplasms through Suppression of YAP1 Signaling and Transcriptional ReprogrammingSemantic proximity Read ↗

GNAS(R201H) and Kras(G12D) cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm.Semantic proximity Read ↗

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Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway.Semantic proximity Read ↗

Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.Semantic proximity Read ↗

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Deep sequencing of cancer-related genes revealed GNAS mutations to be associated with intraductal papillary mucinous neoplasms and its main pancreatic duct dilation.Semantic proximity Read ↗

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